Are there are any four alphabets which can not form English word?

That's a fun challenge! While there are plenty of four-letter combinations that don't form English words, there's no definitive "impossible" combination.

Here's why:

* New words are created all the time. Language is constantly evolving, so what's considered a "word" today might not be tomorrow.

* Proper nouns and technical terms: There are words like "QWERTY" (the keyboard layout) that use unusual letter combinations.

* Scrabble and other games: Some games allow for words not found in dictionaries, like "QAT" or "XYL".

However, some four-letter combinations are extremely unlikely to form English words:

* Consonant-heavy: Four consonants in a row are rare (e.g., "XYZZ").

* Uncommon letter combinations: Certain combinations just don't appear often in English (e.g., "JQKZ").

So, it's more about probability than absolutes. While you can't say for sure that a combination *cannot* become a word, some are far less likely than others!