What is a humorous word play that usually based on several meanings of one word?

That's a great question! The humorous wordplay you're describing is called a pun.

Puns rely on the different meanings of a word or the fact that different words sound alike (but have different meanings). They often create a playful and unexpected twist that makes people chuckle.

Here are some examples:

* "I'm reading a book about anti-gravity. It's impossible to put down!" This pun uses the double meaning of "put down," referring to both setting a book down and stopping reading it.

* "Why don't scientists trust atoms? Because they make up everything!" This pun plays on the word "make up," which can mean "to invent" or "to constitute."

Puns can be silly, clever, or even groan-worthy, but they always aim to make you smile!