Emphasizing destruction:
* The explosion reduced the building to smithereens.
* The angry mob tore the statue to smithereens.
* My hopes for the project were shattered into smithereens.
Emphasizing smallness:
* The cookie crumbled into tiny smithereens.
* The artist meticulously painted each detail, turning the canvas into a masterpiece of smithereens.
* His heart broke into smithereens when he saw her leave.
Emphasizing suddenness:
* The car crashed into the tree, sending it flying into smithereens.
* He slammed the door shut, leaving the vase in smithereens on the floor.
* The news shattered his world into a million smithereens.
Humorously:
* The comedian's jokes reduced the audience to smithereens.
* I'm going to break this news to you gently...but it's all in smithereens.
* The argument broke out over a simple misunderstanding, turning the entire relationship into smithereens.
Ultimately, the best sentence for "smithereens" will depend on the specific situation and the desired effect.