General Difficulty:
1. Pneumonoultramicroscopicsilicovolcanoconiosis: The longest word in the English language, describing a lung disease caused by inhaling very fine silica dust.
2. Queue: This word has a silent "u" and is often confused with "cue."
3. Rhythm: The "th" and "ym" combinations can be tricky.
4. Eerie: The double "e" and silent "e" are easily mispronounced.
5. Aerie: This word, meaning a bird's nest high up, has a silent "e" and is often confused with "airy."
6. Supercalifragilisticexpialidocious: A nonsensical word from Mary Poppins, but nonetheless a challenge to spell!
7. Indispensable: This word has a few unusual letter combinations.
8. Conscientious: The double "s" and the "ti" combination can be tricky.
9. A lot: This two-word phrase is often incorrectly written as "alot."
10. Embarrass: This word is often misspelled as "embarass."
11. Mischievous: The "ie" combination is often mispronounced.
12. Cemetery: The "e" at the end is silent and often omitted.
13. February: The "u" is often forgotten.
14. Definitely: The double "f" and "n" combinations are easily overlooked.
15. Foreign: The silent "e" is often forgotten.
16. Parallel: The double "l" and the "ar" combination can be tricky.
17. Believe: The "ie" combination is often mispronounced.
18. Separate: This word is often misspelled as "seperate."
19. Sacrilegious: The "g" is silent and often forgotten.
20. Accommodate: This word is often misspelled as "acommodate."
Remember: Everyone struggles with different words. The best way to improve your spelling is to read widely, use a dictionary when unsure, and practice writing frequently.