Here are some examples:
* If you mean "to twist a screw":
* Fasten: "He used a screwdriver to fasten the board to the wall."
* Attach: "She attached the knob to the door using a screw."
* Secure: "The carpenter secured the hinges with screws."
* If you mean "to cheat or exploit":
* Rip off: "That store ripped me off with their prices!"
* Take advantage of: "Don't let them take advantage of your kindness."
* Exploit: "He exploited his workers by paying them low wages."
* If you mean "to mess up or ruin":
* Ruin: "Don't ruin your chances by being late."
* Spoil: "The rain spoiled our plans for a picnic."
* Botch: "He botched the entire project."
* If you mean "to be unimportant or insignificant":
* Matter: "It doesn't matter to me what you think."
* Count: "Your opinion doesn't count."
* Signify: "That decision signifies nothing to me."
To give you a more precise synonym, please provide the sentence where "screw" is used.