Here are some examples of how to use it in a sentence:
* "Despite his promises to reform, John still couldn't resist temptation. It seems a leopard can't change its spots." (This implies that John is inherently prone to wrongdoing and his promises are not genuine.)
* "The company's history of unethical practices is well-known. It's like trying to change a leopard's spots; they'll always find a way to cut corners." (This suggests that the company's core values are ingrained and unlikely to change.)
* "I know you're trying to be a better person, but I just don't see it happening. A leopard doesn't change its spots, you know." (This is a harsh statement implying that the person is not capable of real change.)
It's important to remember that this saying is often used to criticize someone's character and can be considered judgmental. It's best to use it sparingly and with caution.