Here's what we know:
* Pocahontas was one of his daughters. She is the most famous of his children, but the exact number of siblings she had is unknown.
* He had many wives. Powhatan, like many Native American leaders, had multiple wives, which is how he likely fathered a large number of children.
* Some sources claim he had 24 children. This number is often cited, but it's based on speculation and not confirmed historical records.
In conclusion: We know Powhatan had a large family, but the exact number of children is unknown and likely impossible to determine with certainty.