It's estimated that there were over 300 different Native American languages spoken across what is now the United States in 1492. These languages belonged to various language families, including:
* Algonquian: Spoken by tribes in the Northeast, Great Lakes, and Plains regions.
* Iroquoian: Spoken by tribes in the Northeast and Southeast.
* Siouan: Spoken by tribes in the Midwest and Plains.
* Muskogean: Spoken by tribes in the Southeast.
* Athabascan: Spoken by tribes in the Southwest and Northwest.
* Na-Dené: Spoken by tribes in the Northwest.
* Uto-Aztecan: Spoken by tribes in the Southwest.
* Salishan: Spoken by tribes in the Northwest.
* Wakashan: Spoken by tribes in the Northwest.
It's important to note that these are just some of the major language families. There were many other smaller language families and isolates present as well.
While we cannot know exactly how many languages were spoken in 1492, it's clear that the land that would become the United States was a linguistically diverse landscape.