How do you say what are doing grandma in Spanish?

There are a couple of ways to say "What are you doing, Grandma?" in Spanish, depending on the level of formality you want to use:

Formal:

* ¿Qué está haciendo, abuela? (This is the most formal and polite way to ask.)

Informal:

* ¿Qué haces, abuela? (This is a more casual and familiar way to ask.)

You could also use "¿Qué andas haciendo, abuela?" which is slightly more informal than "¿Qué haces?" but still respectful.

The choice of which phrase to use depends on your relationship with your grandmother and the situation.