However, depending on the context, there might be more nuanced ways to express it in English:
* "What's the matter?" - This is a common and informal way to ask.
* "Is everything alright?" - This implies concern and might be used when someone seems distressed.
* "What's bothering you?" - This focuses on the specific issue.
* "Are you okay?" - This is a simple and direct way to ask.
The best translation depends on the specific situation and your desired level of formality.