Formal:
* Estou bem, obrigado/a. (male/female) - This is the most common and polite way to say it.
* Estou bem, muito obrigado/a. (male/female) - This is even more polite and adds emphasis.
Informal:
* Estou bem, obrigado/a. (male/female) - This is still polite but more casual.
* Estou bem, valeu. (male/female) - This is very informal and friendly.
* Tudo bem. (male/female) - This means "Everything is fine" and is a common way to respond to "How are you?".
Note: "Obrigado" is used by men and "Obrigada" is used by women.
For example:
* "Como está?" - "How are you?"
* "Estou bem, obrigado." - "I am fine, thank you."