General inquiries:
* Ɛdeɛ na ɛyɛɛ? (ɛ-deɛ na ɛ-yɛɛ?) - This is the most common and direct translation of "what is wrong?". It's a general question asking about a problem or issue.
* Dɛn na ɛyɛ? (dɛn na ɛ-yɛ?) - This is a more informal way to ask "what's up?" or "what's the matter?".
* Ɛyɛ dɛn? (ɛ-yɛ dɛn?) - This is another informal way to ask "what's going on?" or "what's the problem?".
Specific inquiries:
* Ɛdeɛ na ɛrekɔ? (ɛ-deɛ na ɛ-re-kɔ?) - This means "what is happening?" and can be used to ask about a specific situation or event.
* Ɔyɛ dɛn? (ɔ-yɛ dɛn?) - This literally means "what is he/she doing?" and can be used to inquire about someone's well-being or to ask what is wrong with them.
* Ɛyɛ dɛn na ɛrebehia wo? (ɛ-yɛ dɛn na ɛ-re-be-hia wo?) - This means "what is the problem that's bothering you?" and is a more direct and empathetic way to ask what's wrong.
Note: The "ɛ" sound in Twi is a long "e" sound like the "a" in "father".
The choice of phrase will depend on the specific situation and the relationship between the speaker and the listener.