Formal:
* 你快乐吗?(nǐ kuài lè ma?) - This is the most direct and neutral translation.
* 您高兴吗?(nín gāoxìng ma?) - This is a more polite version, used when addressing someone older or in a position of authority.
Informal:
* 你开心吗?(nǐ kāixīn ma?) - This is a more common and casual way to ask.
* 你幸福吗?(nǐ xìngfú ma?) - This is a more profound way to ask about overall happiness and well-being.
To make it even more specific, you can add a subject after the "Are you" part:
* 你工作开心吗?(nǐ gōngzuò kāixīn ma?) - "Are you happy with your work?"
* 你跟朋友在一起开心吗?(nǐ gēn péngyou zài yīqǐ kāixīn ma?) - "Are you happy being with your friends?"
Note: The tone of voice and context will also influence the meaning of the question.