你周末过得怎么样? (nǐ zhōumò guò de zěnme yàng?)
This is a very common and natural way to ask someone how their weekend was.
Here are some other options, depending on the context:
* 周末过得愉快吗? (zhōumò guò de yúkuài ma?) - Did you have a pleasant weekend?
* 周末过得怎么样? (zhōumò guò de zěnme yàng?) - How was your weekend? (more casual)
* 周末做什么了? (zhōumò zuò shénme le?) - What did you do this weekend?
The best choice will depend on the specific situation and your relationship with the person you are talking to.