Formal:
* Meu amigo(a) bondoso(a) e abençoado(a): This is the most literal translation and is quite formal.
* Meu(minha) estimado(a) e abençoado(a) amigo(a): This adds a touch of respect and appreciation.
Informal:
* Meu(minha) bom(boa) e abençoado(a) amigo(a): This is a more casual and affectionate way to say it.
* Meu(minha) amigo(a) querido(a) e abençoado(a): This emphasizes the love and affection you have for your friend.
Note:
* You need to use the correct gender for "friend" (amigo for male, amiga for female) and adjust the adjectives accordingly.
* You can also add a phrase like "de coração" (from the heart) to further emphasize your affection.
Ultimately, the best way to say "my good and blessed friend" in Portuguese depends on your relationship with the person and the context of the conversation.