To complete the sentence, you would need to add what you are comparing. For example:
* Est la différence entre tu et moi? (Is there a difference between you and me?)
* Est la différence entre tu et ton frère? (Is there a difference between you and your brother?)
* Est la différence entre tu et ton travail? (Is there a difference between you and your work?)
Let me know if you have a specific phrase in mind, and I can translate it for you!