Here are some examples:
* "Tengo que elegir una asignatura optativa." - "I have to choose an elective subject."
* "La asignatura de matemáticas es muy difícil." - "The math course is very difficult."
However, "asignatura" can also sometimes be translated as topic, discipline, or field of study.
It's important to consider the context of the sentence to determine the most accurate translation.