It's possible that:
* It's a made-up phrase: It could be a fictional phrase from a book, movie, or TV show.
* It's a misheard phrase: You might have misheard the actual phrase, and "Que Quowle" is not the accurate representation.
* It's a specific slang term: It could be a slang phrase specific to a certain group or location.
To help understand the meaning, please provide more context:
* What is the source of the phrase? (Book, movie, TV show, etc.)
* What is the situation where Jacob says it?
* Who is Jacob?
With more information, I can try to decipher the meaning of "Que Quowle."