Direct translation:
* "What should I do?"
* "What am I supposed to do?"
More context-specific translations:
* "What should I say?"
* "What should I tell them?"
* "How should I handle this?"
* "What am I going to do now?"
More colloquial translations:
* "What the heck am I going to do?"
* "I'm lost, what should I do?"
To provide the most accurate translation, it would be helpful to know more about the situation in which this sentence is being used.