Formal:
* What are you talking about?
* What do you mean?
Informal:
* What are you saying?
* What's up?
* Are you serious?
* You're kidding, right?
* Wow! (Used in a positive way)
Sarcastic:
* Oh really?
* You're telling me?
* Is that so?
The best translation will depend on the situation and the speaker's intentions.