"Now you've really messed up big time" or "You've really screwed up."
It is important to understand that this phrase is extremely offensive and should never be used in polite conversation. It carries a lot of negative connotation and can be seen as a threat or an expression of extreme anger.
If you are looking for a more appropriate and respectful way to express dissatisfaction or frustration, it's important to choose your words carefully and avoid using vulgar language.