Here are some possibilities:
* Continuing Legal Education: This is a common meaning, especially in the legal field.
* Center for Literacy Education: This is another possibility, often used in educational contexts.
* Council on Legal Education: This refers to a specific organization focusing on legal education.
* Cleveland: This is a city in Ohio, USA, and "CLE" is sometimes used as its abbreviation.
* Clean: This is a more informal use of the abbreviation, usually in texting or online chat.
Please provide more context about where you encountered the abbreviation "CLE" so I can give you a more accurate answer.