Formal:
* Je suis très seul(e). (I am very lonely) - This is the most straightforward and polite way to express loneliness.
* Je me sens très seul(e). (I feel very lonely) - This emphasizes the emotional aspect of loneliness.
Informal:
* Je suis tellement seul(e). (I am so lonely) - This is a more intense way to express loneliness.
* Je me sens vraiment seul(e). (I feel really lonely) - This emphasizes the strong feeling of loneliness.
* J'ai tellement le cafard. (I am so down) - This is a colloquial expression that can be used to express loneliness, sadness, and depression.
* Je suis au fond du trou. (I am at the bottom of the hole) - This is a very strong expression that conveys a feeling of extreme loneliness and despair.
Remember to choose the expression that best suits the context and your level of formality.