It can be used in various contexts, such as:
* Return trip: "Mi regreso a casa fue largo." (My return trip home was long.)
* Return of something: "El regreso de la primavera." (The return of spring.)
* Coming back: "El regreso del héroe." (The hero's return.)
* Going back: "El regreso al pasado." (Going back to the past.)
The specific meaning of "regreso" will depend on the context in which it is used.