For general lack of social interaction:
* Unsociable
* Introverted
* Reclusive
* Solitary
* Hermit-like
* Antisocial (though this has a more serious connotation)
For lack of friendliness:
* Unfriendly
* Cold
* Aloof
* Distant
* Reserved
For lack of ease in social situations:
* Awkward
* Shy
* Timid
* Uncomfortable
The best word to use depends on the specific context and what you want to convey.