General Antonyms:
* Isolate: This implies separating or being alone, the opposite of engaging with others.
* Ignore: This suggests not paying attention or acknowledging someone or something.
* Avoid: This implies actively trying to stay away from contact or interaction.
More Specific Antonyms:
* Disengage: This can mean stopping an interaction that's already started.
* Withdraw: This suggests pulling back from a situation or relationship.
* Sever: This implies completely breaking off any connection or relationship.
* Passive: This means not taking an active part in an interaction.
The best antonym depends on the specific meaning of "interact" in your sentence.