General:
* Poor
* Destitute
* Needy
* Indigent
* Underprivileged
* Deprived
* Lacking
More specific:
* Financially: Bankrupt, insolvent, penniless, broke
* Culturally: Uncultivated, unrefined, primitive
* Spiritually: Empty, hollow, barren
* Environmentally: Degraded, depleted, barren
The best synonym will depend on the specific meaning you want to convey.