General:
* Anomaly
* Aberration
* Outlier
* Exception
* Departure
* Divergence
* Variation
* Discrepancy
* Difference
* Irregularity
More specific:
* Abnormality (when referring to something unusual or unhealthy)
* Defiance (when referring to a deliberate act of disobedience)
* Nonconformity (when referring to a refusal to follow the rules or expectations)
* Eccentricity (when referring to unusual or peculiar behavior)
* Idiosyncrasy (when referring to a distinctive feature or habit)
The best word to use will depend on the specific context and the nuance you want to convey.