* For basic communication: No, it doesn't really matter which hand you use. Many signs are symmetrical, meaning they can be done with either hand. It's common for signers to use their dominant hand for the main sign, and their non-dominant hand for support or additional information.
* For specific signs: Yes, some signs are specifically assigned to one hand or the other. This is especially true in ASL (American Sign Language). For example, the sign for "father" is done with the right hand, while the sign for "mother" is done with the left hand.
* For cultural context: Yes, hand use can be culturally significant. In some cultures, using the left hand for certain actions or gestures is considered rude. It's always best to be aware of the local customs and avoid causing offense.
Overall, the most important thing is to be clear and understandable. If you're learning sign language, focus on the correct handshapes and movements, and don't worry too much about which hand you use for every sign. As you become more fluent, you'll naturally start to use the appropriate hand for each sign.