General Synonyms:
* Initial
* Primary
* Foremost
* Leading
* Premier
* Inaugural
* Opening
* Beginning
* Preeminent
More Specific Synonyms:
* Top (when referring to position)
* Earliest (when referring to time)
* Original (when referring to the origin)
* Pioneer (when referring to someone who is the first to do something)
* Inaugurator (when referring to someone who starts something)
Phrases that Mean "First":
* At the outset
* In the beginning
* To start with
* From the get-go
The best word to use will depend on the specific situation and the desired tone.