General synonyms:
* Initial
* Primary
* Preliminary
* Inaugural
* Original
* Leading
* Foremost
* Prior
* Preceding
* Opening
* Beginning
More specific synonyms:
* Pioneer (for someone who does something first)
* Inaugurator (for someone who starts something new)
* Precursor (for something that comes before and influences something else)
* Premiere (for the first public performance of a play, movie, etc.)
* Inauguration (for the formal beginning of a new period or term)
* Genesis (for the origin or beginning of something)
Phrases:
* At the outset
* From the start
* In the beginning
* To begin with
* First and foremost
The best synonym to use will depend on the specific meaning you want to convey.