Formal:
* Firstly,
* Initially,
* At the outset,
* First and foremost,
* To start,
* As a starting point,
* In the beginning,
Informal:
* First off,
* Let's start with,
* For starters,
* First things first,
* Right off the bat,
More specific:
* Concerning... (when introducing a specific topic)
* With regard to... (when focusing on a particular aspect)
* In terms of... (when emphasizing a specific perspective)
Choose the option that best fits the tone and style of your writing.