Formal:
* Ajude-me: This is the most formal and polite way to say "help me."
* Pode me ajudar? This translates to "Can you help me?" and is also a polite and formal way to ask for help.
Informal:
* Me ajuda: This is the most casual and common way to say "help me."
* Dá uma mãozinha: This translates to "Give me a hand" and is a more friendly way to ask for help.
More specific:
* Me ajude com isso: This translates to "Help me with this" and specifies what you need help with.
* Preciso de ajuda: This means "I need help" and is a direct way to ask for assistance.
The best way to say "help me" in Portuguese will depend on your relationship with the person you are asking and the situation.