What word has a similar meaning to breakthough?

Here are some words with similar meanings to breakthrough, depending on the specific context:

General:

* Advance

* Discovery

* Innovation

* Leap forward

* Milestone

* Progress

* Revolution

* Transformation

Scientific:

* Discovery

* Innovation

* New finding

Medical:

* Cure

* Treatment

* Therapy

Business:

* Innovation

* Game-changer

* Disruption

Personal:

* Epiphany

* Realization

* Understanding

The best word to use will depend on the specific context and the nuance you want to convey.