What is a synonym for ailment?

Here are some synonyms for ailment, depending on the context:

General:

* Illness

* Sickness

* Complaint

* Condition

* Affliction

* Disease

* Malaise

More specific:

* Disorder (for a medical condition)

* Discomfort (for a minor issue)

* Indisposition (for a temporary illness)

* Plague (for a serious or widespread illness)

The best synonym will depend on the specific meaning you want to convey.