Here are some examples of sentences using "profoundly":
* "The philosopher's words profoundly affected my understanding of the world." (Modifies the verb "affected")
* "She was profoundly moved by the music." (Modifies the adjective "moved")
* "He was profoundly grateful for her support." (Modifies the adjective "grateful")
* "The research profoundly challenged our assumptions." (Modifies the verb "challenged")
The specific sentence you use will depend on the context and the meaning you want to convey.