What is the negative superlative of familiar?

The negative superlative of "familiar" depends on the context and what you're trying to express. Here are some options:

If you want to express "least familiar":

* Least familiar: This is the most straightforward option.

* Most unfamiliar: This is a more formal way of saying "least familiar."

* Utterly unfamiliar: This emphasizes the complete lack of familiarity.

* Totally alien: This implies a sense of strangeness and unfamiliarity.

If you want to express "most unfamiliar":

* Most unfamiliar: This directly expresses the opposite of "most familiar."

* Most estranged: This emphasizes a sense of separation or distance.

* Most foreign: This implies a complete lack of connection or understanding.

The best choice depends on the specific situation and the nuance you want to convey.