For example:
* "The maniac ran down the street, laughing wildly." (Here, the pronoun would be "he" or "she," depending on the maniac's gender.)
* "They say a maniac escaped from the asylum." (Here, "they" is used because the gender is unspecified.)
It's important to use pronouns that respect the gender identity of the individual, even if they are being described in a negative way.