* General nervousness: The horse was skittish, easily spooked by the flapping plastic bag.
* Reluctance to engage: The investors were skittish about the new project, unsure of its profitability.
* Unpredictability: The market has been skittish all week, fluctuating wildly.
* Describing a person's personality: He was a skittish young man, easily embarrassed and prone to awkwardness.
* Figurative language: The rumor spread like wildfire, making the entire office skittish with anticipation.