General:
* Deviation: This is the most direct and common noun, meaning a departure from a standard, norm, or expected course.
* Divergence: This emphasizes a splitting or branching off from a common point.
* Digression: This specifically refers to a departure from the main topic of discussion.
More specific:
* Aberration: This implies a deviation from what is considered normal or typical, often in a negative way.
* Anomaly: Similar to aberration, this suggests a deviation from what is expected or usual.
* Discrepancy: This emphasizes a difference or inconsistency between two things that should be alike.
The best choice for you will depend on the specific context and the meaning you want to convey.