General annoyance:
* Nakakainis (most common and direct translation)
* Nakakairita (implies something that irritates or bothers)
* Nakakabwisit (stronger, implying something that makes you angry)
* Nakakapikon (implies something that makes you want to punch something)
Other options:
* Makaasar (means "to provoke" or "to tease")
* Makulit (means "pesky" or "clingy")
* Nakakapang-init ng ulo (literally "makes your head hot", means something that makes you angry)
The best word to use depends on the context and the level of annoyance you want to express.