General Antagonism:
* Antagonistic
* Aggressive
* Unfriendly
* Unwelcoming
* Adverse
* Opposed
* Combative
* Belligerent
More Specific:
* Hostile takeover (business) - Takeover, acquisition, seizure
* Hostile environment (workplace) - Toxic, abusive, unsafe
* Hostile fire (military) - Enemy fire, incoming fire
Figurative/Metaphorical:
* Unforgiving
* Inimical
* Unfavorable
* Unwelcoming
* Threatening
The best word choice will depend on the specific context in which you are using it.