If "fulfillment" means a sense of satisfaction or contentment:
* Discontent
* Dissatisfaction
* Emptiness
* Unfulfillment
* Frustration
* Boredom
* Despair
If "fulfillment" means achieving goals or reaching one's potential:
* Failure
* Unsuccess
* Stagnation
* Frustration
* Lack of purpose
If "fulfillment" refers to the completion of a task or obligation:
* Incomplete
* Unfulfilled
* Pending
* Outstanding
The best opposite will depend on the specific context and meaning you want to convey.