General synonyms:
* Escape
* Flee
* Bolt
* Abscond
* Take off
* Make a break for it
* Skip town
* Go on the lam
* Disappear
* Evacuate
* Withdraw
More specific synonyms:
* Elope (for a romantic escape)
* Desert (for leaving a duty or responsibility)
* Defect (for leaving a country or organization)
* Scatter (for running in different directions)
* Break loose (for escaping from captivity)
The best synonym to use will depend on the specific situation and the intended meaning.