For commands:
* Demand: This implies a forceful request, leaving little room for refusal.
* Order: This conveys a sense of authority and expectation of compliance.
* Insist: This suggests a strong insistence, bordering on a demand.
* Command: This is a more formal and direct way to demand something.
For requests:
* Refuse: This is the opposite of "please" in terms of granting a request.
* Decline: This is a more polite way of refusing a request.
* Disregard: This suggests ignoring a request altogether.
* Ignore: Similar to disregard, but emphasizes the lack of response.
The best opposite for "please" will depend on the specific situation and the intended meaning.