If you're talking about being ill:
* Ailing
* Unwell
* Indisposed
* Infirm
* Ill
* Diseased
* Under the weather
* Run down
If you're talking about something unpleasant:
* Repulsive
* Disgusting
* Nauseating
* Loathsome
If you're talking about something that makes you feel nauseous:
* Queasy
* Nauseated
* Sick to one's stomach
If you're talking about someone being mentally ill:
* Mentally unstable
* Disturbed
* Unhinged
* Deranged
It's important to choose the most appropriate synonym depending on the context and the specific meaning you want to convey.