* Simple: The villain's actions were truly despicable.
* With a specific example: His betrayal of his friend was a despicable act.
* Figurative: The dictator's treatment of his people was a despicable stain on history.
* Emphasizing the feeling: The cruelty of the act was so despicable that it made my blood run cold.
* In a negative comparison: Even the worst criminals were less despicable than the person who stole from the orphanage.
Remember, "despicable" is a very strong word. It's used to express extreme moral disapproval.