General synonyms:
* Slow
* Letharargic
* Drowsy
* Inactive
* Languid
* Tired
* Listless
* Heavy
* Unresponsive
* Dull
More specific synonyms:
* For a person: Weary, exhausted, apathetic, indifferent, unmotivated, lazy
* For a machine: Lagging, lagging behind, underperforming, malfunctioning
* For a business: Stagnant, stagnant economy, flat, slow growth, weak
* For a flow (e.g., of traffic): Congested, jammed, backed up, gridlocked
The best word to use will depend on the specific situation and the nuance you want to convey.