General synonyms:
* Protector
* Caretaker
* Custodian
* Keeper
* Overseer
* Watchman
Legal synonyms:
* Trustee
* Conservator
* Executor
* Administrator
Informal synonyms:
* Watchdog
* Shepherd
* Defender
Other options:
* Mentor
* Advocate
* Champion
The best synonym for "guardian" will depend on the specific context in which it is being used.