General Unease:
* Discomfort
* Anxiety
* Apprehension
* Restlessness
* Unease of mind
* Disquiet
* Misgiving
* Trepidation
* Worry
* Nervousness
* Suspicion
More Specific Unease:
* Uncomfortable: When something physical is bothering you
* Wary: When you are cautious about something
* Suspicious: When you don't trust someone or something
* Concerned: When you are worried about something specific
* Disturbed: When something has upset you emotionally
Negative Emotions Related to Unease:
* Fear
* Dread
* Panic
* Anguish
* Distress
* Dismay
* Despair
The best synonym for "unease" depends on the specific context.
For example, if you are describing a feeling of general discomfort, "discomfort" or "restlessness" might be appropriate. If you are describing a feeling of anxiety about a specific event, "apprehension" or "trepidation" might be a better choice.